For decades indispensable, the AMA Manual of Style continues to provide editorial support to the medical and scientific publishing community. Since the 1998 publication of the 9th edition, however, the world of medical publishing has rapidly modernized, and the intersection of research andpublishing has become ever more complex. The 10th edition of the AMA Manual of Style, published in early 2007, brings this definitive manual into the 21st century with a broadened international perspective. In doing so, the 10th edition has expanded its electronic guidelines, with the understanding that authors now routinely submit articles through online systems and often cite Web-only content. Ethical and legal issues receive increased attention, with detailed guidelines on authorship, conflicts ofinterest, scientific misconduct, intellectual property, and the protection of individuals' rights in scientific research and publication. The new edition examines research ethics and editorial independence and features new material on indexing and searching as well as medical nomenclature. JAMA and the Archives Journals, one of the most groups of medical publications in the world, have lent members of their expert staff of professional journal editors to the committee that has produced this edition. Extensively peer-reviewed, the 10th edition provides a welcome and improved standardfor the growing international medical community. More than a style manual, this 10th edition offers invaluable guidance on how to navigate the dilemmas that authors and researchers and their institutions, medical editors and publishers, and members of the news media who cover scientific researchconfront in a society that has thrust these issues center stage.